Journal: Cureus

Article Title: Analytical Verification and Method Comparison of the Atellica HEMA 580 Hematology Analyzer for Routine Clinical Laboratory Implementation in a Tertiary Care Setting

doi: 10.7759/cureus.110761

Figure Lengend Snippet: Scatter plot showing platelet counts measured on the Atellica HEMA 580 plotted against corresponding measurements from the Sysmex XN-3100 for 44 paired clinical samples. The solid line represents the line of best fit derived from ordinary least squares regression. The regression equation, coefficient of determination (R 2 ), and sample size (n) are displayed within the plot. Platelet counts are expressed as ×10 9 /L. Deming regression was used to account for analytical error in both measurement procedures. Correlation is presented for method comparison purposes and should not be interpreted as analytical interchangeability without bias assessment.

Article Snippet: The Sysmex XN-3100, which integrates impedance, optical, and fluorescence measurement principles and has been extensively validated in the literature, served as the comparator analyzer [ - ].

Techniques: Derivative Assay, Comparison

Journal: Cureus

Article Title: Analytical Verification and Method Comparison of the Atellica HEMA 580 Hematology Analyzer for Routine Clinical Laboratory Implementation in a Tertiary Care Setting

doi: 10.7759/cureus.110761

Figure Lengend Snippet: Bland-Altman plot illustrating the difference in platelet counts (Atellica HEMA 580 minus Sysmex XN-3100) plotted against the mean platelet count for 44 paired samples. The solid horizontal line indicates the mean bias, while dashed lines represent the 95% limits of agreement (±1.96 standard deviations). Platelet counts are expressed as ×10 3 /µL. Limits of agreement were calculated as mean bias ±1.96 SD. The observed bias remained within ranges not expected to influence routine clinical platelet transfusion decision thresholds.

Article Snippet: The Sysmex XN-3100, which integrates impedance, optical, and fluorescence measurement principles and has been extensively validated in the literature, served as the comparator analyzer [ - ].

Techniques:

Journal: Cureus

Article Title: Analytical Verification and Method Comparison of the Atellica HEMA 580 Hematology Analyzer for Routine Clinical Laboratory Implementation in a Tertiary Care Setting

doi: 10.7759/cureus.110761

Figure Lengend Snippet: Scatter plot showing platelet counts measured on the Atellica HEMA 580 plotted against corresponding measurements from the Sysmex XN-3100 for 44 paired clinical samples. The solid line represents the line of best fit derived from ordinary least squares regression. The regression equation, coefficient of determination (R 2 ), and sample size (n) are displayed within the plot. Platelet counts are expressed as ×10 9 /L. Deming regression was used to account for analytical error in both measurement procedures. Correlation is presented for method comparison purposes and should not be interpreted as analytical interchangeability without bias assessment.

Article Snippet: Method comparison Strong analytical agreement was observed between the Atellica HEMA 580 and the Sysmex XN-3100 across WBC, RBC, hemoglobin, and platelet measurements based on 44 paired samples.

Techniques: Derivative Assay, Comparison

Journal: Cureus

Article Title: Analytical Verification and Method Comparison of the Atellica HEMA 580 Hematology Analyzer for Routine Clinical Laboratory Implementation in a Tertiary Care Setting

doi: 10.7759/cureus.110761

Figure Lengend Snippet: Bland-Altman plot illustrating the difference in platelet counts (Atellica HEMA 580 minus Sysmex XN-3100) plotted against the mean platelet count for 44 paired samples. The solid horizontal line indicates the mean bias, while dashed lines represent the 95% limits of agreement (±1.96 standard deviations). Platelet counts are expressed as ×10 3 /µL. Limits of agreement were calculated as mean bias ±1.96 SD. The observed bias remained within ranges not expected to influence routine clinical platelet transfusion decision thresholds.

Article Snippet: Method comparison Strong analytical agreement was observed between the Atellica HEMA 580 and the Sysmex XN-3100 across WBC, RBC, hemoglobin, and platelet measurements based on 44 paired samples.

Techniques: